DNA Methylation

Analysis of DNA Methylation

An increasing number of research fields now focus on DNA methylation as a major player in the epigenetic control of gene expression and associated diseases.
BaseClear offers a complete service package for assessing DNA methylation based on the bisulfite conversion method. The bisulfite reaction specifically converts cytosine residues into uracil, leaving all other DNA building block including methylated cytosine unchanged. Following bisulfite conversion, downstream applications like PCR and DNA sequencing can be used to establish specifically where methylated and non-methylated cytosine residues are present in the source material, or to compare the methylation of specific regions between multiple samples. Our fully equipped laboratory will analyze the presence of methylated cytosine residues in the genomic region of your choice employing the ZYMO Research EZ DNA Methylation Kit for bisulfite conversion and various other methods to assess the DNA methylation status.