BaseClear offers complete solutions to help determine the effect of cosmetics, soaps, personal care products, antibiotics, probiotics or other interventions on the skin microbiome. This analysis is required to put a ‘microbiome-friendly’ claim on a product or to demonstrate the efficacy of a product. BaseClear offers services for the entire process including sampling, logistics, sample preparation, collection of metadata, downstream bioinformatics and statistical analysis.

BaseClear also provides consultancy and support for project design. Our product specialists can advise you regarding sampling, sample preparation and the best technical approach to use. We respond fast to inquiries and our focus is to deliver results as fast as possible.

How does your product work on the skin microbiome?

The human skin is home to millions of bacteria, fungi and viruses, which compose the skin microbiota. The skin microbiota is extremely important to the skin health and it plays an essential role in skin protection against external infectious or toxic substances.

It is important to maintain the balance of the skin microbiota in order to preserve the best physiology of the skin. Skin microbial communities are largely stable over time, despite the exposure of the skin to different external environments. However the skin microbiome can be affected by for instance personal care products, antibiotics, cosmetics, soaps and nutrition.

The clinical proof of your product efficacy BaseClear BiaNomics offers a complete solution to demonstrate the real efficacy of your product on the microbiome. Our specialists can give consultancy and support for project design, and we deliver complete reports including optional in-depth bioinformatics analysis.

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Skin microbiome analysis

Experts meeting on skin microbiome

BaseClear has years of expertise in microbiome analysis, including skin microflora analysis. We routinely organise expert meetings wherein scientists and researchers meet, share and discuss microbiome projects. Topics discussed include discovery, technical challenges, clinical trials, marketing, commercialisation and regulations on microbiome-based products.

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Sampling and logistics solutions for skin microbiome analysis projects

BaseClear can help you with the logistics of your research. We offer a non-invasive sampling collection kits that contain all the necessary materials to collect the sample. The kit contains specific instructions for sampling, making sure the sampling is done correctly and uniform. The samples are sent directly back to us for analysis in a standardized way. Besides offering our standard sample collection kit, we can also customize the branding of the kit itself and its contents to suit the needs of your specific project.

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Sampling box BiaNomics

The importance of reliable DNA extraction from skin samples

BaseClear has optimized and validated extraction procedures to extract DNA and RNA from complex samples, such as swabs from skin with low biomass. DNA/RNA extraction is an essential step in skin microbiome analysis projects, since the analysis has no value if the DNA of the different organisms do not represent the actual microbial community. The extraction method can have a strong influence on the quantification of the total bacteria and the abundance estimations of specific groups.

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DNA extraction wutg the microbiomics products from Zymo Research

We translate skin microbiome data to clear results

The BaseClear team includes a number of experienced PhD-level molecular biologists, microbiome specialists and bioinformatics experts. Get in touch with one of our experts to discuss your project or to learn more about our microbiome analysis solutions.

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Statistics for skin microbiome analysis

Typically, the data coming from microbial community studies are high-dimensional and together with associated meta-data can be used to unravel the relation between the microbial composition and/or function with environmental variables or sample characteristics. Using multivariate analyses BaseClear can mine data to stratify individuals in, for example, responders and non-responders based on the abundances of different microbial groups or functional identifiers as well as indicate if the different sample group are significantly different. Furthermore, this analysis facilitates identification of microbial groups or function identifiers that are important drivers of the difference between sample groups.

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Multivariate analysis

Meet Tom van den Bogert!

Tom is our metagenomics and microbiome specialist. He is responsible for the development of new and improved metagenomics and microbial profiling services, which are based on Next-Generation sequencing and related technologies. Tom completed his PhD research at the Laboratory for Microbiology at Wageningen University. He studied community and genomic analysis of the human small intestine microbiota in a project funded by TI Food and Nutrition entitled "Complex fermentations."

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