BaseClear BiaNomics offers a new type of antibiotic resistance gene screening based on complete genome analysis. Our method is much more efficient than the classical screening methods. Our unique antibiotic resistance gene screening service is based on a highly curated CARD database. This service is part of our complete package for genome-based microbial strain characterization.

The use of antibiotics during the last decade has led to antibiotic resistance among microorganisms, which is a growing public health concern worldwide. The mechanisms that enable bacteria to become resistant to antibiotics are quite diverse. The genetic basis for the antibiotic resistance can be either intrinsic, through naturally occurring antibiotic resistance genes, or acquired through transfer of genetic material (e.g. plasmids) from other bacteria in the environment.

Screening for novel antibiotic resistance genes

BaseClear BiaNomics can provide you with information about the location of the antibiotic resistance gene (chromosome or plasmid), identification of novel antibiotic resistance genes, as well as identification of mobile genetic elements that may promote transfer of genomic regions coding for the antibiotic resistance to other organisms. Knowledge of (novel) antibiotic resistance genes helps you to understand how antibiotics function and how bacteria fight them.

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BiaNomics strain characterization

Visualization of antibiotic resistance genes

Results from our strain characterization service can be analysed in our online Genome Explorer. The BaseClear Genome Explorer is an interactive platform that allows easy analysis and visualization of your microbial genomic data. With our antibiotic resistance screening module you can assess the safety of strains. We have a standard visualization tool for antibiotic resistance genes, however the Genome Explorer can also be customized to your wishes.

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BaseClear Antibiotic resistance Genes

Antimicrobial resistance (AMR)

Antimicrobials, such as antibiotics, are essential in human and veterinary medicine for the treatment of infections caused by bacteria. Antimicrobial resistance (AMR) is resistance of a bacterium to an antimicrobial to which it was previously sensitive. To minimize the risk of spreading AMR, the European Food Safety Authority (EFSA) advises to use the least resistant organism whenever possible and that the organisms used in animal feed or used as probiotics should not add to the existent pool of antimicrobial resistance genes that are already present in the environment.

The screening of microorganisms for antibiotic resistance can be very laborious and time consuming. BaseClear BiaNomics services for antibiotic resistance gene screening allows efficient and fast screening of your microbial strains. Using unique bioinformatics tools that are developed by our bioinformatics team, we can determine which antibiotic resistance genes are present in the microbial genome. This genome screening method can dramatically reduce the number of disk diffusion tests required.

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BaseClear Microbiology services

Meet Derek Butler!

Derek is director of the BiaNomics Business Unit. In addition to a PhD in microbiology from the University of Cork he has more than 15 years’ experience working on microbial genomics research projects together with industrial partners.

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