Functional Metagenomics Analysis
Our state-of-the-art functional metagenomics analysis pipeline starts with data quality control and optional host filtering, followed by de novo metagenome assembly, gene prediction and annotation. We then calculate the abundance of the annotated genes in the metagenome sample. Additionally, antimicrobial resistance genes (AMR) and virulence factors are identified from the predicted gene sequences.
- High throughput functional analysis of both human and non-human metagenomic data
- Supports analysis of small to large human or animal clinical trial projects including samples from a wide range of microbiomes
- Dedicated analysis workflows supporting all domains of life, (DNA) virus and phage genes.
- Rigorously validated analysis workflow supported by industry benchmarking
- Statistical associations between abundance and diversity of functional genes and sample metadata
For every sample, we provide:
- Predicted gene sequences and their protein translations
- Annotation of the non-redundant gene catalogue with multiple state-of-the-art databases and functional units including orthologs, modules and pathways
- Functional abundance profiling tables of non-redundant genes and KEGG orthologs, COGs and CAZy subfamilies in Reads Per Kilobase (RPK) and Copies Per Million (CPM)
- Extended resistome and virulence genes analysis using multiple databases
- Custom analysis report with high resolution publication-ready figures and tables
Commercial applications:
- Clinical trials – human or animal
- Discovery of novel industrial enzymes
- Discovery of probiotics
- Food and beverage production
- Antimicrobial resistance screening (AMR)
- Understanding the effects of the addition of antimicrobial ingredients in a product
- Understanding the effects of supplementation with probiotic on gut microbiome
