Nanopore sequencing services

BaseClear offers a complete package of sequencing solutions, including sequencing services based on the innovative technology of Oxford Nanopore Technologies (ONT). Advantages of ONT sequencing are the ultra-long read length, as well as the fast turnaround time. Read lengths are determined by preparation, the longest single read using nanopore sequencing is over 2.000.000 base pairs. This has particular benefits when assembling large, complex genomes, resolving structural variation or wishing to explore large metagenomic communities.

BaseClear offers a complete end-to-end nanopore sequencing workflow including sampling solutions, DNA extraction, library preparation to sequencing and analysis. In addition we provide consultancy and support for project design. Key applications include;

  • Sequencing of large and complex genomes, improve existing assemblies or create accurate de novo assemblies using long reads to resolve challenging regions. Direct sequencing removes the requirement for amplification, eliminating PCR bias.
  • Rapid pathogen analysis. Real-time data streaming allows immediate analysis for rapid access to results, which is of critical importance in outbreak management and disease surveillance.
  • Metagenomics analysis of complex environmental samples. Ultra-long reads enhance species identification. Accurate sub-species level microbe identification from closely related and mixed populations.

Certified service provider for Nanopore sequencing

BaseClear works with the innovative Nanopore sequencing technology of Oxford Nanopore Technologies since 2014. In 2017 BaseClear became the first certified Nanopore sequencing service provider of Oxford Nanopore Technologies (see also BaseClear is deeply experienced with nanopore sequencing, having used the innovative nanopore technology as one of the early adopters.

BaseClear supports a wide range of projects, including structural analysis of synthetic DNA constructs, the rapid assembly of complex microbial genomes as well as large animal genomes and the ultra-large tulip genome, which is 11 times larger than the human genome. We also offer metagenomics analysis of complex environmental samples using nanopore technology.

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Meet Adalberto Costessi!

Adalberto Costessi enjoys working on the interface between technology and its application in his position as Product Manager Genomics and Regulatory Affairs. Adalberto’s roles and responsibilities include Regulatory Affairs projects, and shaping and developing new products using NGS sequencing platforms. His work in Regulatory Affairs has assisted many multinational clients in the food and feed industries draft dossier submissions for regulatory approval and has built up considerable experience in this area. He ensures that the generation of genomics and bioinformatics data are compliant with regulatory requirements and are suitable for supporting dossier preparation for new products based on microbial strains introduced intentionally into the food chain. He has extensive expertise in the technology side of genomics and brings a lot of technical knowledge into his position.

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