Nanopore sequencing

BaseClear works with the innovative Nanopore sequencing technology of Oxford Nanopore Technologies since 2014. In 2017 BaseClear has launched nanopore sequencing as an official service, and invites researchers to submit genomics projects for rapid-turnaround, ultra-long read length, direct nanopore sequencing.

Certified service provider for Nanopore sequencing

In 2017 BaseClear became the first certified Nanopore sequencing service provider of Oxford Nanopore Technologies, that enables provision of nanopore sequencing as a service (see also https://nanoporetech.com/services/providers/baseclear-future-genomics-technologies). BaseClear is deeply experienced with nanopore sequencing, having used the innovative nanopore technology as one of the early adopters. BaseClear supports a wide range of projects, including structural analysis of synthetic DNA constructs, the rapid assembly of complex microbial genomes as well as large animal genomes and the ultra-large tulip genome, which is 11 times larger than the human genome. We also offer metagenomics analysis of complex environmental samples using nanopore technology. BaseClear also develops custom nanopore seuqencing solutions that benefit from the real-time analysis and long read length.

BaseClear works with researchers from mainly Western Europe and offers complete nanopore technology services including sampling, extraction, library preparation to sequencing and analysis. BaseClear also provides consultancy and support for project design, particularly useful if you are new to nanopore technology.

BaseClear Nanopore sequencing certified service provider

APPLICATION OF NANOPORE TECHNOLOGY

Oxford Nanopore Technologies provides real-time, direct sequencing of DNA and RNA.  Read lengths are determined by preparation, the longest single read using nanopore sequencing is now over 2 Mb. This has particular benefits when assembling large, complex genomes, resolving structural variation or wishing to explore large metagenomic communities. Nanopore sequencing technology is particularly useful for:

  • Sequencing of large and complex genomes, improve existing assemblies or create accurate de novo assemblies using long reads to resolve challenging regions. Direct sequencing removes the requirement for amplification, eliminating PCR bias.
  • Rapid pathogen analysis. Real-time data streaming allows immediate analysis for rapid access to results, which is of critical importance in outbreak management and disease surveillance.
  • Metagenomics analysis of complex environmental samples. Ultra long reads enhance species identification. Accurate sub-species level microbe identification from closely related and mixed populations.

New applications are in constant and rapid development, i.e. direct RNA sequencing, DNA modification analysis, targeted sequencing.

Genome analysisMetagenomics

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