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It is now well established that the classic genetic code is not sufficient to explain many complex phenotypes and causes of human diseases. Epigenetic modifications to DNA, such as methylcytosine (5-mC) and hydroxymethylcytosine (5-hmC), must also be considered as they can have profound effects on gene expression and are important for nearly every aspect of biology. These modifications can be stable, inheritable, and passed on to future generations.

With recent advances in sample preparation, high-throughput sequencing, and bioinformatics, researchers looking to study DNA methylation and hydroxymethylation now have several options for investigating these epigenetic modifications on a genome-wide scale. BaseClear and Zymo Research offers a comprehensive suite of epigenetic services, including multiple platforms for 5-mC and 5-hmC analysis for focused, mid-tier, and whole-genome interrogations.

The following technologies offer varying levels of resolving power, with some offering regional estimates of DNA methylation status, while others provide quantitative values at single-nucleotide resolution. 
  • Genome-Wide DNA Methylation Analysis
  • Targeted Sequencing for DNA Methylation Anaylsis
  • Reduced Representation Hydroxymethylation Profiling (RRHP)
  • Genome-Wide 5-hmC CapSeq
  • Bioinformatic

Project example:
A genome-wide search for eigenetically regulated genes in zebra finch using MethylCap-seq and RNA-seq
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