Demonstrate microbiome friendliness with science-based microbiome analysis that provides clear evidence of how your product affects microbial diversity, composition, and ecosystem stability.
Microbiome-Friendly Assessment is a scientific testing service that evaluates whether a product, ingredient, or formulation significantly alters the composition and diversity of the microbiome. Using microbiome sequencing and advanced bioinformatics, BaseClear determines whether microbial communities remain stable and balanced following product exposure. This enables companies to substantiate microbiome-friendly claims with objective, data-driven evidence and gain a deeper understanding of how their products interact with the microbiome.
This service is designed for cosmetic, personal care, pharmaceutical, consumer health, food, nutrition, and ingredient companies developing products that come into contact with the human microbiome. It is particularly valuable for organizations seeking to support product claims, demonstrate microbiome compatibility, differentiate products in the marketplace, or assess microbiome safety during product development and clinical studies.
BaseClear applies validated microbiome sequencing workflows combined with robust statistical and ecological analyses. Microbial communities are profiled before and after treatment using high-throughput sequencing, followed by evaluation of alpha diversity, beta diversity, taxonomic composition, and microbiome stability metrics. By comparing treated and control groups, our scientists determine whether observed microbiome changes are statistically significant and biologically relevant. This approach is based on peer-reviewed methodologies developed specifically for microbiome-friendly product assessment.
Clients receive a comprehensive scientific report including microbial diversity analyses, taxonomic profiles, statistical comparisons, data visualizations, and a clear assessment of microbiome impact. Where appropriate, the report includes a conclusion regarding microbiome friendliness based on predefined analytical criteria, providing evidence that can support product development, scientific publications, regulatory discussions, and marketing claims.
Together, we define the product, target microbiome, study design, and desired outcome. Our experts help determine the most appropriate testing strategy and success criteria for your microbiome-friendly assessment.
You provide study samples collected before and after product use, together with any relevant metadata. Our team reviews the study design to ensure robust microbiome analysis and meaningful statistical comparisons.
Microbial communities are characterized using high-throughput sequencing to determine the composition and diversity of the microbiome. This generates the data required to evaluate how the product influences microbial ecosystems.
We compare treated and control groups using alpha diversity, beta diversity, taxonomic composition, and microbiome stability metrics. This determines whether observed changes are statistically significant and biologically relevant.
You receive a comprehensive report including microbiome diversity analyses, visualizations, statistical results, and a clear conclusion regarding microbiome friendliness. These insights can support product development, scientific publications, and microbiome-friendly product claims.
A personal care company wanted to demonstrate that its product supported skin health without disrupting the natural balance of the skin microbiome. Traditional antimicrobial testing could not determine whether the product preserved microbial diversity and ecosystem stability, which are increasingly important for microbiome-friendly product claims.
BaseClear applied a microbiome-friendly assessment workflow combining high-throughput microbiome sequencing, diversity analysis, and advanced bioinformatics. By comparing microbial communities before and after product use, we evaluated alpha diversity, beta diversity, taxonomic composition, and microbiome stability to determine whether the product caused significant microbiome shifts.
The analysis demonstrated that the product maintained microbiome diversity and community structure while achieving its intended function. These findings provided scientific evidence to support microbiome-friendly product positioning and gave the client a robust dataset for product development, scientific communication, and marketing claims.
End-to-end microbial safety assessment capabilities
Regulatory-ready data generation and interpretation
Integrated wet-lab and bioinformatics expertise
Structured support for EFSA and global submissions
Microbiome friendliness is determined by evaluating whether a product causes significant changes to the composition, diversity, and stability of a microbial community. BaseClear compares microbiome profiles before and after product exposure using sequencing-based analyses, diversity metrics, and statistical testing to assess whether the natural microbial ecosystem remains balanced while the product performs its intended function.
Microbiome-friendly assessments typically include alpha diversity, beta diversity, taxonomic composition, and microbial stability analyses. Alpha diversity measures the richness and evenness of microbial communities, while beta diversity evaluates differences between samples or treatment groups. Together, these metrics provide a comprehensive view of how a product influences the microbiome.
A product can be considered microbiome-friendly even when minor microbiome changes are observed. The assessment focuses on whether changes are statistically significant, biologically relevant, and indicative of ecosystem disruption. Many products naturally influence microbial communities to some degree, but microbiome-friendly products preserve overall diversity, resilience, and community balance.
Microbiome-friendly assessments are typically performed using high-throughput sequencing technologies such as 16S rRNA gene sequencing, ITS sequencing, or shotgun metagenomics. The most appropriate method depends on the study objectives, required taxonomic resolution, and target microbiome. These approaches enable detailed characterization of microbial communities before and after product use.
A microbiome-friendly assessment project delivers a comprehensive scientific report containing microbial diversity analyses, taxonomic profiles, statistical comparisons, and data visualizations. Clients receive a clear interpretation of microbiome impact together with supporting evidence that can be used for product development, scientific publications, regulatory discussions, and microbiome-friendly marketing claims.
SERVICES
Phenotypic assessment of antimicrobial resistance aligned with EFSA guidelines
SERVICES
Phenotypic assessment of antimicrobial and cytotoxic production
Speak with our experts to design a WGS strategy aligned with your regulatory needs. Your first consultation is free and without obligation.
