BaseClear offers high quality services using the latest platform from Pacific Biosciences, the PacBio Sequel. We do not offer services on the PacBio RS II system anymore. With this Pac Bio platform BaseClear offers real-time sequencing of single molecules up to 30 kb. The data has added value for de novo assembly, targeted sequencing, detection of structural variation and the direct detection of base modification. The main advantage of the Pac Bio Sequel system over the PacBio RS II platform is the higher output.

Pac Bio technology applications

Sequencing on the Pac Bio platforms can be used in addition to our services based on the Illumina platforms. True whole genome sequencing with the PacBio systems provides complete and accurate views of all types of genomic variation, revealing SNPs/SNVs, structural variants, mobile elements, haplotypes and variants in low-complexity regions. This allows us to:

  • Perform complete microbial characterization in a single experiment
  • Produce high-quality reference genomes for complete gene discovery
  • Use the Pac Bio technology to create exceptional genome de novo assemblies
  • Resolve structural variation across the complete size spectrum with base pair resolution
  • Reconstruct intact genes and gene clusters
  • Clarify the role of mobile elements in drug resistance and transmission
  • Assess the contribution of DNA modification on pathogenesis
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ADVANTAGES OF OUR PACBIO SEQUENCING SERVICE

  • Long reads from the PacBio Sequel can be used to (almost) closed genomes of bacteria or fungi
  • Extended experience with the Pac Bio sequencing technology
  • Strong bioinformatics team
  • Independent service laboratory (GMP and ISO compliant methods)
  • Extended service and support from our sequencing experts
  • Exceptional data quality
  • Many satisfied customers worldwide

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