Whole Genome Sequencing

Whole Genome Sequencing (WGS) is a cutting-edge technology that offers a complete and detailed view of an organism’s genetic makeup. By analyzing an organism’s full DNA sequence, WGS provides unmatched insights into genetic variations, disease predispositions, and microbial identification. Whether advancing medical research, improving healthcare, or ensuring the quality and safety of microbial strains, WGS is transforming our understanding of biology at a fundamental level. The data produced by WGS is driving innovation across research, clinical applications, and beyond.

With rapid technological advancements continually reducing sequencing costs, WGS has become an essential tool in genomics research. It provides a high-resolution, base-by-base view of the genome, detecting both large-scale and subtle genetic variations that might be missed by more targeted approaches. WGS also supports the discovery of gene regulation mechanisms and enables the rapid generation of data for assembling and analyzing novel genomes.

Bacterial Whole Genome Sequencing

Whole Genome Sequencing (WGS), using Illumina Next-Generation Sequencing (NGS), provides a highly detailed view of bacterial genomes. This method has been validated by BaseClear according to GMP guidelines. This approach is essential for generating accurate reference genomes (de novo sequencing) and detecting genomic changes of functional or taxonomic significance. WGS allows clients to explore a wide range of genetic, functional, and evolutionary questions, from precise microbial identification to studying evolutionary traits and variant detection. It is an invaluable tool for microbial genomics, supporting research and quality control with the highest accuracy, including applications such as fast pathogen testing and rapid genome sequencing for timely results.

Analysis Includes:

  • Whole Genome Analysis: Comprehensive analysis of bacterial genomes.
  • Variant Detection: Identification of SNPs, insertions, deletions, and other genomic variations.
  • Identity confirmation based on whole-genome sequencing information.
  • De novo genome assembly and annotation.

Quality Assurance:

  • The methods used in the Illumina NGS bacterial whole genome sequencing workflow are validated based on GMP guidelines. Possibilities for other sample types can be discussed upon request.
  • BaseClear holds a GMP license for microbial identification.
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