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REASONS TO CHOOSE BASECLEAR AS YOUR SEQUENCING PROVIDER

We have achieved a lot in more than 20 years of DNA sequencing 


1 - Over 20 years of experience as a DNA service laboratory

Founded in 1993 by Erna Barèl and Bas Reichert, BaseClear now has more than 20 years of experience. In all those years we have learned how our customers and partners think and the values to seek in a service provider. Most important are high quality results for a low cost per bp, which are achieved through our experienced workforce and latest sequencing technologies like Illumina Hiseq 2500, Illumina Miseq or PacBio RSII.

However, the proof of our attitude towards our customers and partners lies in the strong relationships we have built throughout the years. Many of our customers have come to us for many years, for high quality results, but also for: 

  • Clear and open communication
  • The ability to act fast when needed
  • Consultancy on experimental design
 

2 - Standard and custom bioinformatics solutions

Our excellent bioinformatics team can assist you with answering a wide range of genomics questions from assembly to comparative genomics, to metagenomics and expression analysis as well as custom analyses. Results are delivered in a secure, fast and comprehensive manner and are the ideal starting point for your downstream interpretation.

Walter Pirovano and his team of bioinformaticians developed custom data-analysis pipelines for internal use as well as for industry partners. These pipelines allow these partners to quickly analyse data from frequent or routine samples. Talking about custom solutions, we offer various free to use in house developed analysis tools. We are proud to mention the following: 

  • SSPACE Standard - Scaffolding of pre-assembled contigs using NGS paired-read data.
  • SSPACE Longread - Scaffolding of pre-assembled contigs using long reads (e.g. PacBio RS reads)
  • GapFiller - Closing gaps within pre-assembled scaffolds
 

We have contributed in many high-impact publications using our tools and services. Read more about these tools and our bioinformatics solutions.

3 – R&D joins forces to increase knowledge and expand our services

With our R&D department we discover opportunities that lie outside our standard production procedures. Currently our research focuses on five topics: synthetic biology; metagenomics; system biology and epigenetics; plant genetics and; virus discovery. We work together with some of the leading institutes on these themes, our partners include for instance Leiden University, Wageningen UR, TNO and NIZO Food Research.

Together with NIZO, BaseClear has developed a complete solution package for microbial genomics research. It offers new approaches in the metagenomics analysis of microbial communities. This collaboration combines the Next Generation Sequencing experience from BaseClear with NIZO’s expertise in the field of proteins, bacteria and processing.

Furthermore, BaseClear participates in various (public) projects like Horizon2020, TKI (Top consortia for Knowledge and Innovation), STW (Foundation for Technological Science) and ZonMw projects. Altogether, our R&D activities allows us to sell ‘yes’ as an answer when customers come with challenging problems.

4 – Safe online data analysis through our interactive platforms

Our bioinformatics specialists have developed an online platform for data analysis. This provides our customers with an easy to use solution to interpret Next Generation Sequencing data online without the need to install software. Currently there are three different portals that provide perfect early stage analysis for viruses, bacteria and fungal genomes. This is not only restricted to single genomes, but also allows the analysis of complete strain collections or metagenomics communities: 
  • BaseClear Genome Explorer – A portal to mine and compare whole genomes.
  • BaseClear metaGenome Browser (BmGB)TM – Multilevel taxonomic analysis across 16S amplicons
  • Virus diasgnostics – On-the-fly analysis of viral communities in plants and animals.
 

Read more on these tools at Interactive Online Platforms.

5 – Great expertise in microbial genome

Throughout the years we have seen thousands of genomes from all possible sources so we are perfectly capable to deliver high quality results and services on each project. However, we have strong focus on microbial genome sequencing (genomes sizes up to 50 Mbp).

The microbial expertise of BaseClear is highlighted by the fact that we have sequenced thousands of bacteria, fungi and viruses. We have developed efficient internal workflows for library preparation, robotics, sequencing and analysis. Therefore we are perfecty capable of delivering high quality data.

Not only we use Illumina data (single pair, paired-end or mate-pair), but we have also access to PacBio sequencing for longer reads to sequence full genomes. When PacBio is used, this data can be combined with Illumina data. Our advanced analysis pipelines and internally developed tools are capable to reduce the number of contigs to a minimum. Discover our microbiological solutions. 

6 - Excellent support from qualified product specialists

Whether you request a small routine test or a complete R&D project, BaseClear’s experienced and highly skilled specialists are at your service. We respond fast to inquiries and our focus is to deliver results as fast as possible. BaseClear offers you much more than the operation of our high-tech equipment. Our product specialists can advise you, both during the project planning stage and implementation of the project regarding sample preparation and the best technical approach to use. We will always be in close contact with our customers to discuss the project details. Due to our experience from the wide variety of projects which we completed since 1993, we can help our customers to design the optimal strategy and assist with the analysis and interpretation of the resulting data.

More reasons to partner with BaseClear

  • Fast and guaranteed delivery times
  • Exceptional data quality with premium RAPID run services
  • Lowest cost per bp
  • Extensive bioinformatics solutions
  • Clear communication
  • Consultancy on experimental design
 

Our Next Generation Sequencing services

  • Genome De Novo Sequencing
  • Re-sequencing
  • Transcriptome analysis
  • Small-RNA sequencing
  • Metagenomics
  • Microbial profiling
  • Microbial sequencing and identification
 

Our service portfolio goes further than Next Generation Sequencing. We also offer:

  • Sanger sequencing
  • Microbial Identification and typing
  • Synthetic biology services
  • Molecular biology like custom and PCR cloning and mutagenesis
  • Various lab products for DNA research

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