DNA purification

DNA purification is the process of removing impurities from DNA samples that may inhibit downstream applications, which was traditionally accomplished using ethanol precipitation. Processes such as ligations, qPCR, library preparations, and sequencing demand pure, top-quality DNA obtained through purification. Although numerous DNA purification kits exist, only a select few can deliver high-concentration, high-quality DNA.

For more details about these products, please find our product catalogue at the bottom of this page.


Zymo Research offers many other unique technologies to facilitate accurate DNA analysis, including DNA markers, DNA polymerases, nucleases, modifying enzymes, and technologies specifically designed for the removal of enzymatic (PCR) inhibitors from impure preparations of DNA. Advantages of these products include:

  • Low elution volumes (>6 µl)
  • No retention volume, therefore no loss of DNA
  • No wash residue carryover
  • Fast and simple protocols (e.g. PCR clean-up within 2 minutes)
  • High yields of extremely pure DNA
  • All components can be ordered individually
  • Kits are available for the isolation of fragment DNA, plasmid DNA and genomic DNA from many different sources
Zymo research Sample Kit

ZymoPURE Plasmid Kits

ZymoPURE™ Plasmid Isolation kits provide the fastest and simplest method available to efficiently isolate transfection quality plasmid DNA from E. coli. These plasmid kits feature our advanced ZymoPURE purification technology, including a modified alkaline lysis system and patented binding chemistry, enabling the recovery of highly concentrated plasmid DNA (up to 6 µg/µl) directly from a spin column using microcentrifuge.


Check out this video that demonstrates how to do plasmid midi & maxipreps in just 16 minutes!

Quick-DNA HMW Magbead Kit

The Quick-DNA HMW Magbead Kit offers the easiest approach to isolate high molecular weight DNA from various sources, including biological fluids, cell cultures, and solid tissues. Advantages of the product include:

  • High Molecular Weight DNA: Extract high molecular weight DNA up to 150 kb from any sample in as little as 40 minutes.
  • Ultra-Pure: Highest DNA yield and purity equipped with RNA removal technology.
  • Third-Generation Sequencing Ready: Optimized and validated for long read sequencing (including Nanopore and SMRT sequencing).
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