RNA purification

Isolation and handling of ribonucleic acid (RNA) has historically been thought to be more difficult than DNA due to the presence of ubiquitous and stable RNases. However, this issue can be remedied if the correct tools are used. Purification of high-quality, intact RNA from biological samples or in vitro reactions is important to the success of all downstream applications. To achieve reproducible, trustworthy results from quantitative RT-PCR, Northern blots, microarrays, and cDNA library prep for Next-Generation sequencing, it is important to use the best RNA purification methods available.

For more details about these products, please find our product catalogue at the bottom of this page.


Scientists at Zymo Research have developed special products that effectively stabilize and preserve RNA in samples prior to purification, as well as a comprehensive portfolio of kits for the purification of high-quality, inhibitor-free RNA from essentially any sample source. Advantages of these products include:

  • Comprehensive portfolio of RNA purification kits suitable for diverse sample sources
  • Utilization of innovative Zymo-Spin™ columns for low-volume elution of ultra-pure RNA devoid of salts and inhibitors
  • Offers both organic- and non-organic-based purification methods for most sample types
  • Kits designed for total RNA isolation, also efficient for recovering small RNAs (≥17 nucleotides)
  • Some kits feature unique protocols for selective enrichment of small RNA (<200 nucleotides), large RNA (>200 nucleotides), or both separately

RNA purification with Direct-zol™

Check out this video that demonstrates how to extract high-quality RNA within just 7 minutes!

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