Based on number of factors including study design and budgets, you need to decide the approach to use in human microbiome studies. Often this choice is between the low-cost microbial profiling (amplicon/16S sequencing) and the high-cost approach of complete metagenome sequencing (shotgun metagenomics).

BaseClear has now launched a new solution that combines the benefits of both approaches. With our new shallow shotgun sequencing service, we offer a thoroughly tested workflow for cost-efficient species-level community profiling and functional analysis for human microbiome studies. With a limited budget it is now possible to answer questions linking the microbiome to human health and disease, including:

  • How does our treatment change the overall microbiome population compared to controls?
  • Do we find back our probiotic species after a week of consumption?
  • How does this particular diet change the alpha and beta diversity in samples?
  • Are we able to eliminate the microbe of interest in the population that received the treatment

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