Identification and typing of bacteria or fungi can be very costly and time consuming, because of growth time of the microorganisms and lab work. ProBase Pharma offers microbial identification services using established as well as innovative techniques under GMP conditions. Our methods are much faster and more reliable than currently used phenotypic methods. ProBase Pharma services are suitable for fast screening of even the most difficult samples.
Microbial strain typing services
To control unwanted bacteria you need to know what the contaminating organism is and how it entered your environment. For this ProBase Pharma offers microbial strain typing services using REP-PCR in combination with 16S sequencing. These techniques use the power of DNA to not only identify the genus and species of contaminants, but also provide deeper, strain-level typing at the same time. This fine degree of resolution applies to environmental isolates, pathogens, spoilage organisms, control strains, beneficial organisms or any other bacteria that are important to the industry. Quality control labs use these strain typing techniques to track and trend microbial contaminations and environmental monitoring isolates.
GMP sequencing services
ProBase Pharma offers a highly precise and reliable GMP sequencing service that covers all steps necessary to determine complete DNA sequences. It is commonly used for confirmation of the sequence and integrity of a gene or plasmid and prior to cloning or transfection into a cell line or viral vector. It is also the method of choice for verification that a gene of interest has been successfully introduced into a target cell or plasmid, or that a genetically modified virus has the desired genetic composition. For regulatory submission of therapeutic proteins and vaccine production, DNA sequencing of the entire plasmid or viral vector is required. In addition, DNA sequencing can be used to confirm the identity and stability of (production) cell lines and for patent submissions.