Even though microbial ecosystems have an enormous diversity, and microbial communities have great application potential, fundamental and applied microbial research have been focused on a very limited number of isolated single strains. This is because of many microorganisms require specific culture conditions or depend on symbiotic interactions for growth and, therefore, are difficult to study. Consequently, the majority if microbial diversity remains uncultured and poorly characterized. This means that we have yet to discover the major fraction of the microbial potential available in nature.

BaseClear now offers culturomics solutions to get access to a greater percentage of microbial potential. Our culturomics solution is a high-scale culture technique with the aim to discover novel microbial strains and their physiological and metabolic properties in samples obtained from, for example, extreme environments.  Culturomics will help to mine and discover new antimicrobial agents, enzymes or bioactive compounds.

 

Unraveling microbial life

BaseClear offers unique solutions for research on complex microbial samples to generate pure cultures at high-scale and with high efficiency. We offer a high-throughput cultivation facilities combined with NGS which enables identification and characterization of isolated strains. BaseClear can unravel microbial life by using, for example, the following variations during culturing;

  • Specific media vs. General media
  • pH range
  • Temperature range
  • Dilutions
  • Pre-treatments and enrichments

Culturomics as complementary method to metagenomics

Culturomics can be used as a complementary technique to metagenome analysis. Metagenome analysis provides genetic information about the abundant microorganisms present in a complex microbial consortium . Due to the challenges to identify the unknown content of microbial communities and low abundant species by metagenomics, culturomics provides some of the missing gaps with the added advantage of enabling to better understand physiological, metabolic, ecological roles and potential industrial applications of the generated cultures.

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Meet Aleksandrina Patyshakuliyeva!

Aleksandrina Patyshakuliyeva is one of our PhD-level product managers. She did a PhD in fungal physiology at Westerdijk Institute, investigating plant biomass utilization by fungi. She has gained a lot of experience working as a postdoctoral researcher at Utrecht University, Wageningen University and NIOO-KNAW and was a visiting researcher in INRA, France and Helsinki University, Finland. During this time, her research centred on applications in sustainable food production, sustainable agriculture and bioremediation. She has explored production of extracellular enzymes, organic acids, siderophores, metabolic pathways and regulators controlling the microbial response to the substrates.

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